Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 115
interventional 104
Observational 10
Registry 1

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Other 35
Drug|placebo 19
Device 16
Procedure 16
Drug 5
Device|Other 3
Device|Procedure 3
placebo|Procedure 2
Behavioral 1
Combination Product|Drug|Other 1
Device|placebo 1
Other|placebo 1
Other|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 26
Spain 8
Canada 7
France 6
Finland 5
Germany 5
NA 5
Turkey 5
Brazil 4
China 4
Denmark 3
Taiwan 3
Belgium 2
Israel 2
Netherlands 2
Norway 2
United Kingdom 2
Australia 1
Brazil|Costa Rica|Ecuador|Egypt|Jordan|Mexico|Panama|Peru 1
Colombia 1
Greece 1
India 1
Ireland 1
Italy 1
Mexico 1
Pakistan 1
Serbia 1
Slovenia 1
Switzerland 1
United States|Canada 1

Sites per Study

Site_count Study_Count
1 76
2 6
3 4
4 2
5 1
6 1
7 2
9 1
10 1
13 1
15 1
16 1
19 1
23 1
25 1
29 1
30 1
31 1
33 1

Phase

Phase Study_Count
N/A 70
Phase 3 18
Phase 4 8
Phase 2 4
Phase 1/Phase 2 2
Early Phase 1 1
Phase 1 1

Number of Arms

Number_of_Arms Count_of_Studies
1 13
2 67
3 16
4 5
NA 3

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.3 Phase.4
Min. 40 7.0000 70 27.00 24.00 53.0000 60.000
1st Qu. 40 28.0000 70 44.75 30.00 147.5000 100.000
Median 40 57.0000 70 62.50 66.00 229.5000 231.500
Mean 40 146.5286 70 62.50 106.75 258.1667 191.375
3rd Qu. 40 100.0000 70 80.25 142.75 303.0000 262.500
Max. 40 3000.0000 70 98.00 271.00 658.0000 278.000

Trial Group Type

group_type Group_Count
Experimental 112
Active Comparator 47
Placebo Comparator 29
No Intervention 15
Other 9
Sham Comparator 3
NA 3

Intervention Model

intervention_model Study_Count
Parallel Assignment 80
Single Group Assignment 13
Crossover Assignment 5
Sequential Assignment 3
Factorial Assignment 2
NA 1

Primary Purpose

primary_purpose Study_Count
Treatment 80
Prevention 8
Diagnostic 6
Basic Science 3
NA 3
Device Feasibility 2
Other 1
Supportive Care 1

Observational Studies

Studies by Country

Country Study_Count
United States 5
Brazil 1
China 1
France 1
Israel 1
Turkey 1

Sites per Study

Site_count Study_Count
1 10

Enrollment Metrics

Measure Observational
Min 10.00
1st Qu 53.25
Median 67.50
Mean 135.90
3rd Qu 122.50
Max 700.00

Observation Model

observational_model Study_Count
Cohort 6
Case-Crossover 1
Case-Only 1
Case Control 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 9
Cross-Sectional 1

Registries

Studies by Country

Country Study_Count
Finland 1

Sites per Study

Site_count Study_Count
1 1

Enrollment Metrics

Measure Registries
Min 84
1st Qu 84
Median 84
Mean 84
3rd Qu 84
Max 84

Registry Model

observational_model Study_Count
Case-Only 1

Time Perspective

time_perspective Study_Count
Prospective 1

Follow-up

target_duration Study_Count
3 Months 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04052620 Voltaren Emulgel 2% Acute Ankle Sprain Non Inferiority Study https://ClinicalTrials.gov/show/NCT04052620 Recruiting GlaxoSmithKline 2020-09-30
NCT03550274 App-based Exercise Intervention for Persons With Acute Ankle Sprain https://ClinicalTrials.gov/show/NCT03550274 Completed Hvidovre University Hospital 2019-08-03
NCT03189784 Ankle Instability Treatment in Patients With Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT03189784 Completed University of Jaén 2018-03-30
NCT03163017 Assessment of Ability of 3D Fluorscopy in Aiding Accurate Syndesmotic Reduction Following Traumatic Ankle Injury https://ClinicalTrials.gov/show/NCT03163017 Completed The University of Texas Health Science Center, Houston 2018-09-11
NCT03152916 Application of 3D Printing Technology in Subtalar Arthrodesis https://ClinicalTrials.gov/show/NCT03152916 Recruiting Southwest Hospital, China 2018-08-30
NCT03038815 The Influence of Stability Boots on Gait Pattern in Healthy Adults https://ClinicalTrials.gov/show/NCT03038815 Completed Institute for Biomechanics, ETH Zürich 2017-06-30
NCT02971943 Classification of Ankle Injury Observed With X-ray Combined With Magnetic Resonance Imaging https://ClinicalTrials.gov/show/NCT02971943 Completed The First Hospital of Hebei Medical University 2016-01-31
NCT02930486 Ziptight or Tricortical Screw Fixation of Acute Tibiofibular Syndesmotic Injury https://ClinicalTrials.gov/show/NCT02930486 Completed Vestre Viken Hospital Trust 2017-09-30
NCT02896998 Routine Versus on Demand Removal of the Syndesmotic Screw https://ClinicalTrials.gov/show/NCT02896998 Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 2020-01-31
NCT02810002 Assessing Foot Injuries in Infantry Recruits Wearing Different Boots https://ClinicalTrials.gov/show/NCT02810002 Completed Medical Corps, Israel Defense Force 2015-02-28
NCT02682303 Effect of Elastic Bandage on Balance in Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT02682303 Completed Universidad Rey Juan Carlos 2016-05-31
NCT02645097 Ideal Anatomic Location for Saphenous Nerve Blocks: A Prospective Clinical Evaluation https://ClinicalTrials.gov/show/NCT02645097 Completed Milton S. Hershey Medical Center 2016-12-31
NCT02609308 Lateral Ankle Sprain and Platelet Rich Plasma https://ClinicalTrials.gov/show/NCT02609308 Completed Universidad Autonoma de Nuevo Leon 2016-12-31
NCT02433964 Evaluation of Therapeutic Effects of LED (627 +/- 10nm) The Initial Phase of the Ankle Sprains Treatment https://ClinicalTrials.gov/show/NCT02433964 Completed Universidade do Vale do Paraíba 2012-11-30
NCT02393846 Topical Ketoprofen Versus Placebo in Patients With Ankle Sprain https://ClinicalTrials.gov/show/NCT02393846 Completed Akdeniz University 2015-06-30
NCT02307955 Firefly ANKLE Sprain Study https://ClinicalTrials.gov/show/NCT02307955 Completed Firstkind Ltd 2016-01-31
NCT02276339 Muscle Activation in Chronic Ankle Instability and the Effect of an Exercise Programme https://ClinicalTrials.gov/show/NCT02276339 Completed University College Dublin 2015-11-30
NCT02266290 Effect of Kinesio® Taping in Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT02266290 Completed Universidad Rey Juan Carlos 2013-09-30
NCT02252276 Effects of Manual Therapy and Exercise in the Treatment of Ankle Sprains https://ClinicalTrials.gov/show/NCT02252276 Completed University of Alcala 2014-04-30
NCT02246361 Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication https://ClinicalTrials.gov/show/NCT02246361 Completed Floralis 2015-05-31
NCT02244008 Accumulative Effects of Talus Mobilization https://ClinicalTrials.gov/show/NCT02244008 Completed Federal University of Minas Gerais 2013-12-31
NCT02100670 A Multicenter Efficacy Study of a Diclofenac+Menthol Gel in Subjects With Ankle Sprain https://ClinicalTrials.gov/show/NCT02100670 Completed GlaxoSmithKline 2015-03-01
NCT02097940 Influence of Sensorimotor Treatment in the Balance of Soccer https://ClinicalTrials.gov/show/NCT02097940 Completed Universidade Estadual de Londrina 2014-03-31
NCT01275924 Tightrope or Screw Fixation of Acute Tibiofibular Syndesmotic Injury https://ClinicalTrials.gov/show/NCT01275924 Completed Sykehuset Asker og Baerum 2015-03-31
NCT01272934 Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Ankle Sprain https://ClinicalTrials.gov/show/NCT01272934 Completed Novartis 2011-08-31
NCT02056795 Study of Effects of Electroacupuncture on Balance in Subjects With Chronic Functional Ankle Instability https://ClinicalTrials.gov/show/NCT02056795 Completed Canadian Memorial Chiropractic College 2013-03-31
NCT01995318 Effectiveness of Kinesiotaping in the Treatment of Acute Ankle Sprains https://ClinicalTrials.gov/show/NCT01995318 Completed Etimesgut Military Hospital 2013-07-31
NCT01987570 Effect of Allopurinol Administration on the Prevention of Muscle Mass Loss in Subject Immobilized. https://ClinicalTrials.gov/show/NCT01987570 Completed Instituto de Investigacion Sanitaria La Fe 2016-07-31
NCT01957215 Efficacy of Topical Indomethacin Patch Over Placebo in Ankle Sprain Pain Relief https://ClinicalTrials.gov/show/NCT01957215 Completed GlaxoSmithKline 2014-09-30
NCT01945034 5% Topical Ibuprofen (IBU) for Ankle Sprain https://ClinicalTrials.gov/show/NCT01945034 Completed Pfizer 2015-02-28
NCT01853462 Effects of Two Supervised Training Programs for the Rehabilitation of Ankle Sprains https://ClinicalTrials.gov/show/NCT01853462 Completed Aristotle University Of Thessaloniki 2015-11-30
NCT03527121 Management of Acute Lateral Ankle Sprains https://ClinicalTrials.gov/show/NCT03527121 Active, not recruiting Slagelse Hospital 2019-12-15
NCT01742650 Screw Versus Tightrope Syndesmotic Injury Fixation in Weber C Ankle Fractures https://ClinicalTrials.gov/show/NCT01742650 Completed University of Oulu 2011-12-31
NCT01666197 Efficacy and Safety of Diclofenac Potassium 25 mg Tablet Taken Three Times Daily in Subjects With Acute Joint Pain https://ClinicalTrials.gov/show/NCT01666197 Completed Novartis 2013-01-31
NCT01586390 Functional Treatment for Acute Ankle Sprains: Softcast Wrap Versus MOKcast https://ClinicalTrials.gov/show/NCT01586390 Completed Spaarne Gasthuis 2010-12-31
NCT01563289 Efficacy and Safety of Ibuprofen in Patients With Ankle Injuries https://ClinicalTrials.gov/show/NCT01563289 Completed Orion Corporation, Orion Pharma 2012-07-31
NCT01562717 Efficacy and Safety of Ibuprofen in Patients With Ankle Injuries https://ClinicalTrials.gov/show/NCT01562717 Completed Orion Corporation, Orion Pharma 2012-10-31
NCT01561365 Applicability of the Ottawa Ankle Rules https://ClinicalTrials.gov/show/NCT01561365 Completed Hadassah Medical Organization 2004-05-31
NCT01518335 Use of Platelet Rich Plasma Therapy for Acute Ankle Sprains in the Emergency Department https://ClinicalTrials.gov/show/NCT01518335 Completed Albert Einstein Healthcare Network 2012-01-31
NCT01499966 Comparison of Plaster of Paris Against Tubigrip for the Treatment of Lateral Ankle Sprains https://ClinicalTrials.gov/show/NCT01499966 Completed Liaquat National Hospital & Medical College 2011-07-31
NCT01438905 Effect of Joint Mobilization in the Treatment of Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT01438905 Completed Creighton University 2012-11-30
NCT01423513 Effects of Ankle Support on Muscle Activation and Function https://ClinicalTrials.gov/show/NCT01423513 Completed Creighton University 2012-03-31
NCT01405274 Impact of Physiotherapy Intervention for Children With Ankle Sprains https://ClinicalTrials.gov/show/NCT01405274 Completed McGill University Health Centre/Research Institute of the McGill University Health Centre 2016-03-31
NCT03626935 3D Printed Guide in Ankle Arthrodesis https://ClinicalTrials.gov/show/NCT03626935 Active, not recruiting Southwest Hospital, China 2018-10-31
NCT04363398 Prevention of Patellar and Achilles Tendinopathies in Youth Basketball https://ClinicalTrials.gov/show/NCT04363398 Completed Sport Injury Prevention Research Centre 2018-07-31
NCT04362488 Evaluation of Ankle Propriocement and Stability https://ClinicalTrials.gov/show/NCT04362488 Recruiting Istituto Ortopedico Rizzoli 2020-08-04
NCT04314960 Functional Electrical Stimulation in Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT04314960 Recruiting Ariel University 2022-06-30
NCT04302961 Effects of Gait Retraining With Auditory Feedback https://ClinicalTrials.gov/show/NCT04302961 Recruiting University of North Carolina, Charlotte 2021-03-31
NCT04257916 Manual Therapy, Kinesiotape and Strength Training in Soccer Players With Recurrent Ankle Sprains https://ClinicalTrials.gov/show/NCT04257916 Recruiting Investigación en Hemofilia y Fisioterapia 2020-04-30
NCT04230538 Plaster Cast Versus DJO Walker in Paediatric Ankle Injuries https://ClinicalTrials.gov/show/NCT04230538 Recruiting Sheffield Children’s NHS Foundation Trust 2019-03-05
NCT04167202 Hydrotherapy With Hydrogen-rich Water vs. RICE Protocol Following Acute Ankle Sprain https://ClinicalTrials.gov/show/NCT04167202 Completed University of Novi Sad, Faculty of Sport and Physical Education 2020-01-01
NCT04131842 External Versus Internal Feedback in Patients With Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT04131842 Recruiting University of North Carolina, Charlotte 2022-04-30
NCT04126837 Ankle Trauma: an Emergency Nurse Assessment Study https://ClinicalTrials.gov/show/NCT04126837 Recruiting University Hospital, Grenoble 2021-01-31
NCT04021511 Early Prescription of Radiography Using the Ottawa Ankle Rules by a Nurse in the Management of Isolated Ankle Trauma https://ClinicalTrials.gov/show/NCT04021511 Completed Centre Hospitalier de Saint-Brieuc 2019-09-06
NCT03948503 Mulligan Concept in the Treatment of Ankle Sprains https://ClinicalTrials.gov/show/NCT03948503 Recruiting Université Catholique de Louvain 2019-07-31
NCT03872973 The Effect of Visual Input in Athletes With Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT03872973 Completed Hacettepe University 2019-06-10
NCT03815526 The Immediate Effects of Applying Dynamic Tape, Kinesio Tape and Sport Tape With Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT03815526 Recruiting Taipei Medical University WanFang Hospital 2019-12-31
NCT03808454 The Effect of Proprioception of Platelet Rich Plasma for Patients With Ankle Sprain https://ClinicalTrials.gov/show/NCT03808454 Recruiting National Defense Medical Center, Taiwan 2020-04-06
NCT03663361 Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation https://ClinicalTrials.gov/show/NCT03663361 Recruiting University of Kentucky 2022-12-31
NCT03643926 Arthroscopic Versus Open Brostrom for Ankle Instability https://ClinicalTrials.gov/show/NCT03643926 Recruiting Federal University of São Paulo 2021-07-01
NCT03641066 Progressing Ankle Brace Restriction on Walking and Running Gait Characteristics in Healthy Individuals https://ClinicalTrials.gov/show/NCT03641066 Completed Sport and Spine Rehab Clinical Research Foundation 2018-09-01
NCT03634280 Efficacy of Kinesio Taping and Splinting in Ankle Sprain https://ClinicalTrials.gov/show/NCT03634280 Completed Istanbul Bilgi University 2018-08-01
NCT03626051 Ankle Taping and Functional Ankle Instability https://ClinicalTrials.gov/show/NCT03626051 Completed National Yang Ming University 2017-05-29
NCT03564015 Smartphone App to Improve Functional Outcomes in Ankle Sprains https://ClinicalTrials.gov/show/NCT03564015 Recruiting Lawson Health Research Institute 2022-12-31
NCT03522753 Staple Versus Suture Closure for Foot and Ankle Surgery https://ClinicalTrials.gov/show/NCT03522753 Active, not recruiting University of Alabama at Birmingham 2020-06-01
NCT03447652 A Study Investigating The Effects Of An Ankle Rehabilitation Program On High School Athletes With Ankle Instability https://ClinicalTrials.gov/show/NCT03447652 Completed Georgia State University 2018-08-13
NCT03446469 Influence of Fascial Manipulation on Postural Sway and Ankle Range of Motion https://ClinicalTrials.gov/show/NCT03446469 Completed Manipal University 2018-04-15
NCT03415464 Prevention of Musculoskeletal Injuries in Slovenian Armed Forces https://ClinicalTrials.gov/show/NCT03415464 Completed University of Ljubljana 2018-07-30
NCT01259752 Compression Stockings in Ankle Sprain https://ClinicalTrials.gov/show/NCT01259752 Completed Assistance Publique - Hôpitaux de Paris 2012-07-31
NCT01255423 Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied 4 Times Daily in Subjects With Acute Ankle Sprain https://ClinicalTrials.gov/show/NCT01255423 Completed Novartis 2011-06-30
NCT01249573 The Effect of Fascia Therapy and Transcutaneous Fibrolysis on Acute Ankle Sprain https://ClinicalTrials.gov/show/NCT01249573 Completed University Ghent 2011-03-31
NCT01234493 Syndesmotic Injury and Fixation in Supination-External (SE) Ankle Fractures https://ClinicalTrials.gov/show/NCT01234493 Completed University of Oulu 2010-08-31
NCT01198834 MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains https://ClinicalTrials.gov/show/NCT01198834 Completed MEDRx USA, Inc. 2011-06-30
NCT01134653 A Comparison of Early Mobilization Versus Traditional Treatment for Acute Ankle Sprains. https://ClinicalTrials.gov/show/NCT01134653 Completed Nationwide Children’s Hospital 2014-06-30
NCT01092676 Regular vs Intermittent Dose Ibuprofen for the Treatment of Ankle Sprains in Children https://ClinicalTrials.gov/show/NCT01092676 Completed Lawson Health Research Institute 2016-06-30
NCT01092286 Effect of Neuromuscular Warm-up on Injuries in Female Athletes https://ClinicalTrials.gov/show/NCT01092286 Completed Ann & Robert H Lurie Children’s Hospital of Chicago 2009-07-31
NCT01066520 TAASS-Traumeel Ointment and Gel Compared With a Topical NSAID in Athletes With Acute Ankle Sprain https://ClinicalTrials.gov/show/NCT01066520 Completed Biologische Heilmittel Heel GmbH 2011-09-30
NCT01037816 FS-67 in the Treatment of Pediatric Patients With Ankle Sprain https://ClinicalTrials.gov/show/NCT01037816 Completed Hisamitsu Pharmaceutical Co., Inc. 2010-11-30
NCT00986791 Alcohol Cessation Intervention in an Acute Surgical Setting https://ClinicalTrials.gov/show/NCT00986791 Completed Bispebjerg Hospital 2016-01-01
NCT00955513 Evaluate the Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel Applied Twice or Three Times Daily in Patients With Acute Ankle Sprain https://ClinicalTrials.gov/show/NCT00955513 Completed Novartis 2009-12-31
NCT00954330 Surgical Versus Functional Treatment for Acute Ruptures of the Lateral Ligament Complex of the Ankle in Young Males - A Randomized Controlled Trial With a Mean of 14 Years Follow-up https://ClinicalTrials.gov/show/NCT00954330 Completed Finnish Defense Forces 2008-12-31
NCT00927641 HKT-500 in the Treatment of Adult Patients With Ankle Sprain https://ClinicalTrials.gov/show/NCT00927641 Completed Hisamitsu Pharmaceutical Co., Inc. 2010-11-30
NCT00906672 Medico Economic Evaluation of Dermal Substitute Integra® for Coverage of Inferior Limb Traumatic Skin Loss https://ClinicalTrials.gov/show/NCT00906672 Completed University Hospital, Bordeaux 2014-01-31
NCT00869180 Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Ankle Sprain https://ClinicalTrials.gov/show/NCT00869180 Completed Cerimon Pharmaceuticals 2009-06-30
NCT00847769 Ankle Sprains and Corticospinal Excitability https://ClinicalTrials.gov/show/NCT00847769 Completed University of Southern California 2011-08-31
NCT02091674 Management of Acute Ankle Sprain With Sodium Hyaluronate https://ClinicalTrials.gov/show/NCT02091674 Completed Lawson Health Research Institute 2014-03-31
NCT03307499 NeoPatch Used as Adjunct in Foot and Ankle Tendon Surgery https://ClinicalTrials.gov/show/NCT03307499 Completed CryoLife, Inc. 2018-12-31
NCT02187406 Ankle Athletic Taping Fatigue After a Standard Tennis Warm up https://ClinicalTrials.gov/show/NCT02187406 Completed CEU San Pablo University 2014-09-30
NCT04139044 The Effects of Unilateral Balance Training Among Athletes With Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT04139044 Completed Yeditepe University 2019-06-14
NCT00785876 Implementation of the Low Risk Ankle Rule https://ClinicalTrials.gov/show/NCT00785876 Completed The Hospital for Sick Children 2011-11-30
NCT00732017 Effects Of High Voltage Pulsed Current On Post-Traumatic Injuries https://ClinicalTrials.gov/show/NCT00732017 Completed Universidad Industrial de Santander 2006-09-30
NCT00718302 A Multicenter Randomized Trial Comparing Antiglide and Lateral Plate Fixation in Ankle Fractures https://ClinicalTrials.gov/show/NCT00718302 Completed Boston Medical Center 2012-12-31
NCT00690651 Rest Easy: Is Bed Rest Really Necessary After Surgical Repair of an Ankle Fracture? https://ClinicalTrials.gov/show/NCT00690651 Completed The Alfred 2010-01-31
NCT00680784 HKT-500 in Adult Patients With Ankle Sprain https://ClinicalTrials.gov/show/NCT00680784 Completed Hisamitsu Pharmaceutical Co., Inc. 2008-11-30
NCT00639028 Comparative Study of Two Radiological Modalities, Ultrasonography Versus Stress Radiography, in the Urgent Care and Prognosis of Lateral Ankle Sprain (TALOS) https://ClinicalTrials.gov/show/NCT00639028 Completed University Hospital, Grenoble 2013-12-31
NCT00601471 Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability https://ClinicalTrials.gov/show/NCT00601471 Completed University of Virginia 2010-01-31
NCT00573768 Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel in Patients With Acute Ankle Sprain https://ClinicalTrials.gov/show/NCT00573768 Completed Novartis 2007-12-31
NCT00446797 Open Label Comparative Study On Celecoxib Efficacy And Safety Vs Non-Selective NSAID In Acute Pain Due To Ankle Sprain https://ClinicalTrials.gov/show/NCT00446797 Completed Pfizer 2008-04-30
NCT00432705 Changes in Unstable Ankles After Balance Training https://ClinicalTrials.gov/show/NCT00432705 Completed University of North Carolina, Charlotte 2007-09-30
NCT00351104 Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain https://ClinicalTrials.gov/show/NCT00351104 Completed APR Applied Pharma Research s.a. 2007-02-28
NCT00336752 Operative Versus Non Operative Treatment for Unstable Ankle Fractures https://ClinicalTrials.gov/show/NCT00336752 Completed Lawson Health Research Institute 2010-08-31
NCT00261560 A Safety and Effectiveness Study of Acetaminophen Extended Release (3900 mg/Day) and Ibuprofen (1200 mg/Day) in the Treatment of Pain Associated With Ankle Sprains. https://ClinicalTrials.gov/show/NCT00261560 Completed Johnson & Johnson Consumer and Personal Products Worldwide NA
NCT02324270 Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain https://ClinicalTrials.gov/show/NCT02324270 Completed Actavis Inc. 2014-12-31
NCT00797368 Manual Therapy and Exercise Versus Home Exercises in the Management of Patients Status Post Ankle Sprain https://ClinicalTrials.gov/show/NCT00797368 Completed Franklin Pierce University 2012-06-30

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT04095598 Computed Tomography With Stress Maneuvers for Evaluation of Distal Tibiofibular Syndesmosis Instability (CTMETS) https://ClinicalTrials.gov/show/NCT04095598 Recruiting Hospital Israelita Albert Einstein 2022-12-31
NCT03312933 Associated Joint Pain With Controlled Ankle Movement (CAM) Walker Boot Wear https://ClinicalTrials.gov/show/NCT03312933 Completed Brigham and Women’s Hospital 2016-03-18
NCT03259750 The Foot and Ankle Ability Measure (FAAM) is Translated From English to Turkish and Assess the Validity and Reliability in Athletic Population Who Have Foot and Ankle Disorders. https://ClinicalTrials.gov/show/NCT03259750 Completed Hasan Kalyoncu University 2014-05-20
NCT04455386 Diagnostic Study of Lateral Ligament Complex Injury of Ankle https://ClinicalTrials.gov/show/NCT04455386 Recruiting Peking University Third Hospital 2020-12-31
NCT01779804 Triage-Based Application of OFAR on the Number of Radiographs Ordered https://ClinicalTrials.gov/show/NCT01779804 Completed Lehigh Valley Hospital 2013-09-30
NCT01658709 Predicting Ankle Injury Through Clinical Functional Measures in Adolescent Athletes https://ClinicalTrials.gov/show/NCT01658709 Active, not recruiting University of Toledo Health Science Campus 2030-09-30
NCT04209582 Transcutaneous Oxygen Pressure of the Injured Ankle as Predictor of Postoperative Cutaneous Pain https://ClinicalTrials.gov/show/NCT04209582 Recruiting Nantes University Hospital 2021-12-01
NCT03711747 Indications for Osteochondral Allograft Transplantation https://ClinicalTrials.gov/show/NCT03711747 Recruiting University of Missouri-Columbia 2020-10-01
NCT00556010 Intraoperative Three Dimensional Fluoroscopy Compared to Standard Fluoroscopy for the Assessment of Reduction of Ankle Fractures With Syndesmosis Disruption https://ClinicalTrials.gov/show/NCT00556010 Completed Hadassah Medical Organization 2011-07-31
NCT00494403 Chronic Ankle Instability and Proprioception https://ClinicalTrials.gov/show/NCT00494403 Completed Logan College of Chiropractic 2010-08-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02330198 Validation of the Foot and Ankle Ability Measure Tool in Finnish https://ClinicalTrials.gov/show/NCT02330198 Completed Turku University Hospital 2015-11-30